Publications

2024

Cross-disorder and disease-specific pathways in dementia revealed by single-cell genomics
Cross-disorder and disease-specific pathways in dementia revealed by single-cell genomics
Rexach JE, Cheng Y, Chen L, Polioudakis D, Lin LC, …, Vinters H, Trojanowski JQ, Seeley WW, Malhotra D, Geschwind DH
Cell  ·  09 Sep 2024  ·  doi:10.1016/j.cell.2024.08.019
Single-cell genomics and regulatory networks for 388 human brains
Single-cell genomics and regulatory networks for 388 human brains
Emani PS, Liu JJ, Clarke D, Jensen M, Warrell J, …, Dursun C, Lou S, (13 authors), Cheng Y, et al.
Science  ·  24 May 2024  ·  doi:10.1126/science.adi5199
Molecular cascades and cell-type specific signatures in autism spectrum disorders revealed by single cell genomics
Molecular cascades and cell-type specific signatures in autism spectrum disorders revealed by single cell genomics
Wamsley B, Bicks L, Cheng Y, Kawaguchi R, Quintero D, …, Xiao S, Hawken N, Margolis M, Mazariegos S, and Geschwind DH
Science  ·  24 May 2024  ·  doi:10.1126/science.adh26

2023

The Intermittent Fasting Mimetic, 2-deoxyglucose, Reprograms Brain Derived Neurotrophic Factor (BDNF) transcription via an Adaptive ER Stress-ATF4 Pathway and Improves Outcomes in Alzheimer's and Stroke Models
The Intermittent Fasting Mimetic, 2-deoxyglucose, Reprograms Brain Derived Neurotrophic Factor (BDNF) transcription via an Adaptive ER Stress-ATF4 Pathway and Improves Outcomes in Alzheimer's and Stroke Models
Kumar A, Karuppagounder SS, Chen Y, Corona C, Kawaguchi R, …, Ming G, Tuvikene J, Timmusk T, Geschwind DH, Ratan RR
Neuron  ·  11 Jul 2023  ·  doi:10.1016/j.neuron.2023.06.013
Integrin-driven Axon Regeneration in the Spinal Cord Activates a Distinctive CNS Regeneration Program
Integrin-driven Axon Regeneration in the Spinal Cord Activates a Distinctive CNS Regeneration Program
Cheah M (co-first), Cheng Y (co-first), Petrova V, Cimpean A, Jendelova P, Swarup V, Woolf CJ, Geschwind DH, Fawcett JW
Journal of Neuroscience (cover)  ·  28 Jun 2023  ·  doi:10.1523/JNEUROSCI.2076-22.2023

2022

Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration
Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration
Cheng Y, Yin Y, Zhang A, Bernstein AM, Kawaguchi R, …, Goldberg JL, Woolf CJ, Sofroniew MV, Benowitz LI, Geschwind DH
Nature Communications  ·  29 Jul 2022  ·  doi:10.1038/s41467-022-31960-7
Core Transcription Programs Controlling Injury-Induced Neurodegeneration of Retinal Ganglion Cells
Core Transcription Programs Controlling Injury-Induced Neurodegeneration of Retinal Ganglion Cells
Feng Tian, Yuyan Cheng, Songlin Zhou, Qianbin Wang, Aboozar Monavarfeshani, …, Daniel Taub, Clifford J. Woolf, Joshua R. Sanes, Daniel H. Geschwind, Zhigang He
Neuron  ·  22 Jan 2022  ·  doi:10.1101/2022.01.20.477004

2020

Toll-like receptor 2 (TLR2)-deficiency impairs male mouse recovery from a depression-like state
Toll-like receptor 2 (TLR2)-deficiency impairs male mouse recovery from a depression-like state
Eva M. Medina-Rodriguez, Yuyan Cheng, Suzanne M. Michalek, Eléonore Beurel, Richard S. Jope
Brain, Behavior, and Immunity  ·  01 Oct 2020  ·  doi:10.1016/j.bbi.2020.05.068

2019

Insulin growth factor 2 (IGF2) as an emergent target in psychiatric and neurological disorders. Review
Insulin growth factor 2 (IGF2) as an emergent target in psychiatric and neurological disorders. Review
M. Pardo, Y. Cheng, Y.H. Sitbon, J.A. Lowell, S.F. Grieco, R.J. Worthen, S. Desse, A. Barreda-Diaz
Neuroscience Research  ·  01 Dec 2019  ·  doi:10.1016/j.neures.2018.10.012

2018

TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice
TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice
Yuyan Cheng, Sachi Desse, Ana Martinez, Ryan J. Worthen, Richard S. Jope, Eleonore Beurel
Brain, Behavior, and Immunity  ·  01 Mar 2018  ·  doi:10.1016/j.bbi.2018.02.003

2017

Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway Development
Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway Development
Kun-Che Chang, Jonathan Hertz, Xiong Zhang, Xiao-Lu Jin, Peter Shaw, …, Alexandra Dreyfuss, Mohammed S. Uddin, Kenneth J. Muller, Derek M. Dykxhoorn, Jeffrey L. Goldberg
The Journal of Neuroscience  ·  14 Apr 2017  ·  doi:10.1523/JNEUROSCI.3430-13.2017
Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice
Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice
Marta Pardo, Yuyan Cheng, Dmitry Velmeshev, Marco Magistri, Hagit Eldar-Finkelman, Ana Martinez, Mohammad A. Faghihi, Richard S. Jope, Eleonore Beurel
JCI Insight  ·  23 Mar 2017  ·  doi:10.1172/jci.insight.91782
Stressed and Inflamed, Can GSK3 Be Blamed?
Stressed and Inflamed, Can GSK3 Be Blamed?
Richard S. Jope, Yuyan Cheng, Jeffrey A. Lowell, Ryan J. Worthen, Yoel H. Sitbon, Eleonore Beurel
Trends in Biochemical Sciences  ·  01 Mar 2017  ·  doi:10.1016/j.tibs.2016.10.009
Up-regulation of insulin-like growth factor 2 by ketamine requires glycogen synthase kinase-3 inhibition
Up-regulation of insulin-like growth factor 2 by ketamine requires glycogen synthase kinase-3 inhibition
Steven F. Grieco, Yuyan Cheng, Hagit Eldar-Finkelman, Richard S. Jope, Eléonore Beurel
Progress in Neuro-Psychopharmacology and Biological Psychiatry  ·  01 Jan 2017  ·  doi:10.1016/j.pnpbp.2016.08.008

2016

Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior
Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior
Yuyan Cheng, Marta Pardo, Rubia de Souza Armini, Ana Martinez, Hadley Mouhsine, Jean-Francois Zagury, Richard S. Jope, Eleonore Beurel
Brain, Behavior, and Immunity  ·  01 Mar 2016  ·  doi:10.1016/j.bbi.2015.12.012

2015

A pre-conditioning stress accelerates increases in mouse plasma inflammatory cytokines induced by stress
A pre-conditioning stress accelerates increases in mouse plasma inflammatory cytokines induced by stress
Yuyan Cheng, Richard S Jope, Eleonore Beurel
BMC Neuroscience  ·  07 May 2015  ·  doi:10.1186/s12868-015-0169-z

2014

Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments
Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments
Margaret K. King, Marta Pardo, Yuyan Cheng, Kimberlee Downey, Richard S. Jope, Eléonore Beurel
Pharmacology & Therapeutics  ·  01 Jan 2014  ·  doi:10.1016/j.pharmthera.2013.07.010